Anti-KAT13A / SRC1 Monoklonale Antilichaam

Boster Bio Anti-KAT13A / SRC1 Monoclonal Antibody catalog # M00856. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Angiopoietin-1; ANG-1; ANGPT1; KIAA0003

NCOA1

8648

Q15788

Human

A synthesized peptide derived from human KAT13A / SRC1 Nuclear receptor coactivator that ly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) .

Clone: AEHD-14

KMT4 / Dot1L Antibody detects endogenous levels of total KMT4 / Dot1L

WB, IHC, IP

Acetylation, Cancer, Cancer Metabolism,2339, Chromatin Modifying Enzymes, Co-Activators/Co-Repressors, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Signaling Pathway, Transcription

Affinity-chromatography

0.5mg/ml

Liquid

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00856

57513 MW

157 kDa

Angiopoietin-1

Secreted.

Glycogen synthase kinase-3 beta (gsk3b)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.