Anti-KCNN4 Antibody Picoband® 0,00647 Vervoeging

Intermediate conductance calcium-activated potassium channel protein 1 (KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel; KCNN4; IK1, IKCA1, KCA4, SK4

KCNN4

3783

O15554

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4, different from the related mouse and rat sequences by two amino acids.

Widely expressed in non-excitable tissues.

Flow Cytometry

Cell Biology, Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Immunogen affinity purified.

Liquid

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. .

1. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. Joiner, W.J., Wang, L.Y., Tang, M.D. and Kaczmarek, L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. U.S.A.1997; 94 (20), 11013-11018. 2. Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U.S.A.2003; 100 (12), 7366-7371. 3. Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J. Biol. Chem.2004; 279 (15), 15531-15540.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

47696 MW

No cross reactivity with other proteins.

6

Intermediate conductance calcium-activated potassium channel protein 4

Membrane; Multi-pass membrane protein.

Belongs to the integrin alpha chain family.

Intermediate conductance calcium-activated potassium channel protein 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.