Anti-Keratocan/KTN/Kera Antibody Picoband®

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene. The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2) .

Boster Bio Anti-Keratocan/KTN/Kera Antibody Picoband® catalog # A07712-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Protein Hook homolog 3; h-hook3; Hhk3; HOOK3

Kera

16545

O35367

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Keratocan/KTN/Kera recombinant protein (Position: R73-K115) .

Highly expressed in chromaffin cells of the adrenal medulla (at protein level) . Detected in peripheral sympathetic ganglia (at protein level) . Found in some paracrine cells in stomach and duodenum (at protein level) .

WB, ELISA

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) . May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) .

1. Dudakova, L., Palos, M., Hardcastle, A. J., Liskova, P. Corneal endothelial findings in a Czech patient with compound heterozygous mutations in KERA. (Letter) Ophthalmic Genet. 35: 252-254, 2014. 2. Funderburgh, J. L., Perchellet, A. L., Swiergiel, J., Conrad, G. W., Justice, M. J. Keratocan (Kera), a corneal keratan sulfate proteoglycan, maps to the distal end of mouse chromosome 10. Genomics 52: 110-111, 1998. 3. Khan, A. O., Al-Saif, A., Kambouris, M. A novel KERA mutation associated with autosomal recessive cornea plana. Ophthal. Genet. 25: 147-152, 2004. Note: Erratum: Ophthal. Genet. 25: 289 only, 2004; Ophthal. Genet. 26: 195 only, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A07712-1

49229 MW

41 kDa

Hook microtubule tethering protein 3

Cytoskeleton. Golgi apparatus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.