Anti-KHDRBS2 Antilichaam

Boster Bio Anti-KHDRBS2 Antibody catalog # A09665. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

KH domain-containing, RNA-binding, signal transduction-associated protein 2; Sam68-like mammalian protein 1; SLM-1; hSLM-1; KHDRBS2; SLM1

KHDRBS2

Q5VWX1

Human, Mouse

A synthetic peptide of human KHDRBS2 (NP_689901.2) .

Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.

WB, IHC

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly (A) and poly (U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity) . Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A09665

38927 MW

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Nucleus

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2