Anti-KIF4A/4B Antibody Picoband® fluoro550 Vervoeging

Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene. This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.

Interferon regulatory factor 9; IRF-9; IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; Transcriptional regulator ISGF3 subunit gamma; IRF9; ISGF3G

KIF4A/4B

24137/285643

O95239/Q2VIQ3

Human

No cross-reactivity with other proteins.

E.coli-derived human KIF4A/4B recombinant protein (Position: K729-D1174) .

Leukocytes.

Flow Cytometry

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Immunogen affinity purified.

Liquid

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

1. Ha, M. J., Yoon, J., Moon, E., Lee, Y. M., Kim, H. J., Kim, W. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. Cytogenet. Cell Genet. 88: 41-42, 2000. 2. Kim, W., Tang, Y., Okada, Y., Torrey, T. A., Chattopadhyay, S. K., Pfleiderer, M., Falkner, F. G., Dorner, F., Choi, W., Hirokawa, N., Morse, H. C., III. Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein. J. Virol. 72: 6898-6901, 1998. 3. Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N., Todokoro, K. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J. 23: 3237-3248, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

43696 MW

6

Interferon regulatory factor 9

Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta.

Interferon regulatory factor 9

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.