Anti-kinectine 1/KTN1 Antibody Picoband® fluoro488 Vervoeging

Kinectin is a protein that in humans is encoded by the KTN1 gene. This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene.

Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2

KTN1

3895

Q86UP2

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins.

E.coli-derived human Kinectin 1/KTN1 recombinant protein (Position: K283-K827) .

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

1. Futterer, A., Kruppa, G., Kramer, B., Lemke, H., Kronke, M. Molecular cloning and characterization of human kinectin. Molec. Biol. Cell 6: 161-170, 1995. 2. Ong, L.-L., Er, C. P. N., Ho, A., Aung, M. T., Yu, H. Kinectin anchors the translation elongation factor-1-delta to the endoplasmic reticulum. J. Biol. Chem. 278: 32115-32123, 2003. 3. Plitz, T., Pfeffer, K. Intact lysosome transport and phagosome function despite kinectin deficiency. Molec. Cell. Biol. 21: 6044-6055, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39125 MW

6

Matrix metallopeptidase 16

Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.

RNA-binding protein Musashi homolog 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.