Anti-KLF15 Antibody Picoband® 0,00647 Vervoeging

Kruppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Kruppel-like factor family. KLF15, a kidney-enriched Krüppel-like zinc finger-containing transcription factors, is a transcriptonal activator that binds the CLCNKA promoter. The nuclear protein KLF15, is expressed primarily in liver, heart, skeletal muscle and kidney tissues but is not detected in lymphoid tissues or bone marrow. It is an important regulator of GLUT4 in both adipose and muscle tissues.Although the calculated molecular mass of KLF15 is 44 kDa, the apparent molecular mass on SDS–PAGE is 65 kDa due to the post-translational modifications.

DNA replication licensing factor MCM5; CDC46 homolog; P1-CDC46; MCM5; CDC46

KLF15

28999

Q9UIH9

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human KLF15 recombinant protein (Position: M1-C323) .

Ubiquitous.

Flow Cytometry

ER Proteins, Golgi Proteins, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Interacts with MCMBP.

1. Dmitriev, P., Petrov, A., Ansseau, E., Stankevicins, L., Charron, S., Kim, E., Bos, T. J., Robert, T., Turki, A., Coppee, F., Belayew, A., Lazar, V., Carnac, G., Laoudj, D., Lipinski, M., Vassetzky, Y. S. The Kruppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy. J. Biol. Chem. 286: 44620-44631, 2011. 2. Fisch, S., Gray, S., Heymans, S., Haldar, S. M., Wang, B., Pfister, O., Cui, L., Kumar, A., Lin, Z., Sen-Banerjee, S., Das, H., Petersen, C. A., Mende, U., Burleigh, B. A., Zhu, Y., Pinto, Y. M., Liao, R., Jain, M. K. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc. Nat. Acad. Sci. 104: 7074-7079, 2007. Note: Erratum: Proc. Nat. Acad. Sci. 104: 13851 only, 2007. 3. Jeyaraj, D., Haldar, S. M., Wan, X., McCauley, M. D., Ripperger, J. A., Hu, K., Lu, Y., Eapen, B. L., Sharma, N., Ficker, E., Cutler, M. J., Gulick, J., and 9 others. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483: 96-99, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

28461 MW

6

Minichromosome maintenance complex component 5

Nucleus. Cytosol.

Breast cancer metastasis-suppressor 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.