Anti-KLHL12/C3Ip1 Monoklonale Antilichaam

Boster Bio Anti-KLHL12/C3Ip1 Monoclonal Antibody catalog # A08568. Tested in WB, ELISA applications. This antibody reacts with Human.

Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR; KLHL12; C3IP1

KLHL12

Q53G59

Human

Purified recombinant fragment of human KLHL12 expressed in E. Coli.

Clone: 2G2

Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. .

WB, ELISA

Ascitic fluid

1 mg/mL

Liquid

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR (KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR (KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) . As part of the BCR (KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR (KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08568

63277 MW

Kelch-like protein 12

Cytoplasmic vesicle, COPII-coated vesicle .

IgG1

Ascitic fluid containing 0.03% sodium azide.