Anti-L1TD1 Antibody Picoband® fluoro550 Vervoeging

L1TD1 is an RNA-binding protein highly and specifically expressed in pluripotent cells. It is essential for maintaining the pluripotentency in human embryonic stem cells (hESCs) and has been considered as a markerfor undifferentiated hESCs. L1TD1 is also reported to be highly expressed in medulloblastoma cells and its expression in medulloblastoma correlates with poor clinical outcome.

Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/l; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; H3FJ

L1TD1

54596

Q5T7N2

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human L1TD1 recombinant protein (Position: D34-H852) .

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

Flow Cytometry

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, RNA Processing

Immunogen affinity purified.

Liquid

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

1. Casarotto, M. , Lupato, V. , Giurato, G. , Guerrieri, R. , Sulfaro, S. , & Salvati, A. , et al. (2022) . Line-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer. Clinical Epigenetics, 14 (1), 1-13. 2. Mckerrow, W. , Wang, X. , Mendez-Dorantes, C. , Mita, P. , Cao, S. , & Grivainis, M. . (2022) . Line-1 expression in cancer correlates with p53 mutation, copy number alteration, and s phase checkpoint. Proceedings of the National Academy of Sciences of the United States of America. (8), 119.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Histone cluster 1 H3 family member a/b/c/d/e/f/g/h/i/j

Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.