Anti-Lamine LAMA1 Monoklonale antilichamen

Laminin is a heterotrimeric extracellular matrix protein consisting of 3 chains: alpha-1, beta-1 and gamma-1, formerly called beta-2 (LAMA2) . This gene is over 260,000 base pairs and contains 64 exons. Laminin is similar with merosin, a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve, and both of them are members of the same family of basement membrane proteins. And merosin is the same as laminin M, a striated muscle-specific, basal-lamina-associated protein, it may play a primary role in the pathogenesis of that disorder.

Boster Bio Anti-Laminin LAMA1 Monoclonal Antibody catalog # MA1054. Tested in IHC applications. This antibody reacts with Human, Pig.

Laminin subunit beta-2; Laminin chain B3; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta; S-LAM beta; Lamb2

LAMA1; LAMA2; LAMB1; LAMB2

Human (284217), Mouse (16772), Rat (316758), Human (3908), Mouse (16773), Rat (309368), Human (3912), Mouse (16777), Rat (298941), Human (3913), Mouse (16779), Rat (25473)

P15800

Human, Pig

No cross-reactivity with other proteins

Human laminin.

Clone: LAM-89

Found in the basement membranes (major component) . S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.

IHC

Angiogenesis, Cardiovascular, Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Intermediate Filaments, Neuroscience, Signal Transduction

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

1. Zhang, X.; Vuolteenaho, R.; Tryggvason, K. : Structure of the human laminin alpha-2-chain gene (LAMA2), which is affected in congenital muscular dystrophy. J. Biol. Chem. 271: 27664-27669, 1996. 2. Ehrig, K.; Leivo, I.; Argraves, W. S.; Ruoslahti, E.; Engvall, E. : Merosin, a tissue-specific basement membrane protein, is a laminin-like protein. Proc. Nat. Acad. Sci. 87: 3264-3268, 1990. 3. Arahata, K.; Hayashi, Y. K.; Mizuno, Y.; Yoshida, M.; Ozawa, E. : Dystrophin-associated glycoprotein and dystrophin co-localisation at sarcolemma in Fukuyama congenital muscular dystrophy. (Letter) Lancet 342: 623-624, 1993.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1054

196474 MW

68 kDa

No cross reactivity with other proteins.

Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, feline, pig

Laminin subunit beta-2

Secreted, extracellular space, extracellular matrix, basement membrane.

Contains 17 laminin EGF-like domains.

Laminin subunit alpha-1; Laminin subunit alpha-2; Laminin subunit beta-1; Laminin subunit beta-2

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.