Anti-LAMP1 Antibody Picoband® 0,00647 Vervoeging

LAMP1 (lysosomal-associated membrane protein 1) also called LAMPA, LGP120 or CD107A, is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.  CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells. By means of in situ hybridization, Mattei et al. (1990)   assigned the  LAMP1  gene to chromosome 13q34. A related gene, which may be a pseudogene, mapped to chromosome 12p13.3. Hybridization of  LAMP1  cDNA to chromosome 12p13.3 was observed even when probes representing different portions of the  LAMP1  cDNA were used.

Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a; LAMP1

LAMP1

3916

P11279

Human, Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human LAMP1, different from the related mouse and rat sequences by one amino acid.

Expressed in breast, ovary and prostate.

Flow Cytometry

Protein Trafficking, Signal Transduction, Stem Cells, Subcellular Markers, T Lymphocytic Lineage, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

1. Bermingham, N. A., Martin, J. E., Fisher, E. M. C. The mouse lysosomal membrane protein 1 gene as a candidate for the motorneuron degeneration (mnd) locus. Genomics 32: 266-271, 1996. 2. Mattei, M.-G., Matterson, J., Chen, J. W., Williams, M. A., Fukuda, M. Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively. J. Biol. Chem. 265: 7548-7551, 1990. 3. Yogalingam, G., Bonten, E. J., van de Vlekkert, D., Hu, H., Moshiach, S., Connell, S. A., d'Azzo, A. Neuraminidase 1 is a negative regulator of lysosomal exocytosis. Dev. Cell 15: 74-86, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44882 MW

No cross reactivity with other proteins.

6

Lysosome-associated membrane glycoprotein 1

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.

Belongs to the peptidase S1 family. Kallikrein subfamily.

Lysosome-associated membrane glycoprotein 1 (LAMP-1)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.