Anti-LASS5 CERS5 Antilichaam

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.

Boster Bio Anti-LASS5 CERS5 Antibody (Catalog # A08612) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Trh4, LASS5, Ceramide synthase 5, LAG1 longevity assurance homolog 5, CerS5

CERS5

Q8N5B7

Human, Mouse, Rat

Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.

LASS5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human LASS5. The immunogen is located within the last 50 amino acids of LASS5.

Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.

ELISA, WB, IF

Homeostasis

LASS5 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity) . .

LASS5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08612

45752 MW

Ceramide synthase 5

Nucleus membrane

Ceramide synthase 5

IgG

LASS5 Antibody is supplied in PBS containing 0.02% sodium azide.