Anti-LGI4 Antilichaam

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Boster Bio Anti-LGI4 Antibody (Catalog # A12305) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

LGIL3, LGIL3, UNQ6515/PRO21485, Leucine-rich repeat LGI family member 4, LGI1-like protein 3

LGI4

Q8N135

Human, Mouse, Rat

Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

LGI4 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LGI4. The immunogen is located within amino acids 470 - 520 of LGI4.

Widely expressed, with highest expression in brain.

ELISA, WB

Neuroscience

LGI4 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Component of Schwann cell signaling pathway (s) that controls axon segregation and myelin formation (By similarity) .

LGI4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A12305

59141 MW

Leucine-rich repeat LGI family, member 4

Secreted .

Leucine-rich repeat LGI family, member 4

IgG

LGI4 Antibody is supplied in PBS containing 0.02% sodium azide.