Anti-LIF Antibody Picoband® 31.0550 Vervoeging

LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. This gene is mapped to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. LIF could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface.

Leukemia inhibitory factor; LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin; LIF; HILDA

LIF

3976

P15018

Human

No cross-reactivity with other proteins

E.coli-derived human LIF recombinant protein (Position: S23-F202) . Human LIF shares 78% and 82% amino acid (aa) sequences identity with mouse and rat LIF, respectively.

Widely distributed in various tissues.

Flow Cytometry

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Differentiation, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Neurogenesis, Neurology Process, Neuroscience, Transcription, Tumor Suppressors

Immunogen affinity purified.

Liquid

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

1. Bamberger, A.-M., Jenatschke, S., Schulte, H. M., Loning, T., Bamberger, C. M. Leukemia inhibitory factor (LIF) stimulates the human HLA-G promoter in JEG3 choriocarcinoma cells. J. Clin. Endocr. Metab. 85: 3932-3936, 2000. 2. Sutherland, G. R., Baker, E., Hyland, V. J., Callen, D. F., Stahl, J., Gough, N. M. The gene for human leukemia inhibitory factor (LIF) maps to 22q12. Leukemia 3: 9-13, 1989.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22008 MW

No cross reactivity with other proteins.

6

Leukemia inhibitory factor

Secreted.

Belongs to the LIF/OSM family.

Leukemia inhibitory factor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.