Anti-LIN28B Antibody Picoband® 31.0550 Vervoeging

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

ATP-binding cassette sub-family C member 8; Sulfonylurea receptor 1; ABCC8; HRINS; SUR; SUR1

LIN28B

389421

Q6ZN17

Human

No cross-reactivity with other proteins.

E.coli-derived human LIN28B recombinant protein (Position: E23-K249) .

Flow Cytometry

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Channels, Diabetes, Diabetes-associated, Drug Metabolism, Energy Transfer Pathways, Heart Disease, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Subunit of the beta-cell ATP-sensitive potassium channel (KATP) . Regulator of ATP-sensitive K (+) channels and insulin release.

1. Basak, A., Munschauer, M., Lareau, C. A., Montbleau, K. E., Ulirsch, J. C., Hartigan, C. R., Schenone, M., Lian, J., Wang, Y., Huang, Y., Wu, X., Gehrke, L., and 9 others. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature Genet. 52: 138-145, 2020. 2. Guo, Y., Chen, Y., Ito, H., Watanabe, A., Ge, X., Kodama, T., Aburatani, H. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene 384: 51-61, 2006. 3. Molenaar, J. J., Domingo-Fernandez, R., Ebus, M. E., Lindner, S., Koster, J., Drabek, K., Mestdagh, P., van Sluis, P., Valentijn, L. J., van Nes, J., Broekmans, M., Haneveld, F., and 18 others. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nature Genet. 44: 1199-1206, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

ATP binding cassette subfamily C member 8

Cell membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.