Anti-LMCD1 Antilichaam (C-term)

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity) . Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Boster Bio Anti-LMCD1 Antibody (C-term) (Catalog # A08888) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

LIM and cysteine-rich domains protein 1, Dyxin, LMCD1

LMCD1

Q9NZU5

Human, Mouse, Rat

This LMCD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 316-350 amino acids from the C-terminal region of human LMCD1.

Expressed in the heart (at protein level) . Expressed in many tissues with highest abundance in skeletal muscle

WB

Neuroscience, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity) . Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08888

40833 Da

WB: 1:1000

Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus.

Rabbit IgG

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.