Anti-LPO Antibody Picoband® fluoro488 Vervoeging

Lactoperoxidase is a peroxidase enzyme secreted from mammary, salivary and other mucosal glands including the lungs, bronchii and nose that functions as a natural and the first line of defense against antibacterial and antiviral agents. Lactoperoxidase is a member of the heme peroxidase family of enzymes. In humans, lactoperoxidase is encoded by the LPO gene. This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

ATP-binding cassette sub-family G member 8; Sterolin-2; ABCG8

LPO

4025

P22079

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence in the middle region of human LPO.

Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359) . Low expression levels in the small intestine and colon (PubMed:11099417) . Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359) .

Flow Cytometry

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cholesterol Metabolism, Heart Disease, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg2+- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092) . Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092) . The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356) .

1. Dull, T. J., Uyeda, C., Strosberg, A. D., Nedwin, G., Seilhamer, J. J. Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. DNA Cell Biol. 9: 499-509, 1990. 2. Ueda, T., Sakamaki, K., Kuroki, T., Yano, I., Nagata, S. Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase. Europ. J. Biochem. 243: 32-41, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

75679 MW

6

ATP binding cassette subfamily G member 8

Membrane ; Multi-pass membrane protein .

ATP-binding cassette sub-family G member 8

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.