Anti-LRIG1 Antibody Picoband® 31.0550 Vervoeging

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It is mapped to 3p14.1. Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family, MET and RET. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

LRIG1

26018

Q96JA1

Human

E.coli-derived human LRIG1 recombinant protein (Position: K79-E906) . Human LRIG1 shares 89.8% amino acid (aa) sequence identity with mouse LRIG1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Guo, D., Holmlund, C., Henriksson, R., Hedman, H. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. Genomics 84: 157-165, 2004. 2. Jensen, K. B., Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc. Nat. Acad. Sci. 103: 11958-11963, 2006. 3. Nilsson, J., Vallbo, C., Guo, D., Golovleva, I., Hallberg, B., Henriksson, R., Hedman, H. Cloning, characterization, and expression of human LIG1.Biochem. Biophys. Res. Commun. 284: 1155-1161, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.