Anti-LRP5 Antibody Picoband® fluoro488 Vervoeging

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

Low-density lipoprotein receptor-related protein 5; LRP-5; LRP5; LR3, LRP7

LRP5

4041

O75197

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5, identical to the related mouse and rat sequences.

Widely expressed, with the highest level of expression in the liver and in aorta. .

Flow Cytometry

Signaling Pathways, Stem Cells, Structures, Surface Molecules, Visual System

Immunogen affinity purified.

Liquid

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. .

1. Hey PJ, Twells RC, Phillips MS, Yusuke Nakagawa, Brown SD, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF (Oct 1998) . Cloning of a novel member of the low-absorbance lipoprotein receptor family. Gene 216 (1) : 103–11. 2. Entrez Gene: LRP5 low absorbance lipoprotein receptor-related protein 5 3. Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., III, Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., Wu, D. Low-absorbance lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway. Molec. Cell 7: 801-809, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

179145 MW

No cross reactivity with other proteins.

6

Low-density lipoprotein receptor-related protein 5

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum . Chaperoned to the plasma membrane by MESD. .

Belongs to the LDLR family.

Low-density lipoprotein receptor-related protein 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.