Anti-LSM11 Antibody Picoband® fluoro488 Vervoeging

LSM11 is a component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing .Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cellcycle progression from G1 to S phases.

LSM11

134353

P83369

Human, Rat

E.coli-derived human LSM11 recombinant protein (Position: A17-Q360) . Human LSM11 shares 88.4% amino acid (aa) sequence identity with mouse LSM11.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Hartz, P. A. Personal Communication. Baltimore, Md. 3/15/2018. 2. Pillai, R. S., Grimmler, M., Meister, G., Will, C. L., Luhrmann, R., Fischer, U., Schumperli, D. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev. 17: 2321-2333, 2003. 3. Uggenti, C., Lepelley, A., Depp, M., Badrock, A. P., Rodero, M. P., El-Daher, M.-T., Rice, G. I., Dhir, S., Wheeler, A. P., Dhir, A., Albawardi, W., Fremond, M.-L., and 44 others. cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing. Nature Genet. 52: 1364-1372, 2020.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.