Anti-LZTS2 Antilichaam

The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

Boster Bio Anti-LZTS2 Antibody (Catalog # A07806) . Tested in ELISA, IHC-P applications. This antibody reacts with Human.

LAPSER1, KIAA1813, LAPSER1, Leucine zipper putative tumor suppressor 2, Protein LAPSER1, hLZTS2

LZTS2

Q9BRK4

Human

LZTS2 antibody is predicted to not cross-react with other LZTS family members.

LZTS2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LZTS2. The immunogen is located within amino acids 570 - 620 of LZTS2.

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.

ELISA, IHC-P

Cancer, Cell Cycle

LZTS2 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A07806

72759 MW

Leucine zipper, putative tumor suppressor 2

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Bovine, Mouse, Rat

Leucine zipper, putative tumor suppressor 2

IgG

LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.