Anti-M Cadherine/CDH15 Antibody Picoband® fluoro647 Vervoeging

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene. This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

CDH15

1013

P55291

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human M Cadherin/CDH15 recombinant protein (Position: L61-D742) .

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

1. Bhalla, K., Luo, Y., Buchan, T., Beachem, M. A., Guzauskas, G. F., Ladd, S., Bratcher, S. J., Schroer, R. J., Balsamo, J., DuPont, B. R., Lilien, J., Srivastava, A. K. Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. Am. J. Hum. Genet. 83: 703-713, 2008. 2. Donalies, M., Cramer, M., Ringwald, M., Starzinski-Powitz, A. Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Proc. Nat. Acad. Sci. 88: 8024-8028, 1991. 3. Hollnagel, A., Grund, C., Franke, W. W., Arnold, H.-H. The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Molec. Cell. Biol. 22: 4760-4770, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17B

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.