Anti-MADD Antibody Picoband®

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

Boster Bio Anti-MADD Antibody Picoband® catalog # A02030-1. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

MADD

8567

Q8WXG6

Human, Mouse, Rat

E.coli-derived human MADD recombinant protein (Position: K5-Y329) .

WB, Flow Cytometry, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Al-Zoubi, A. M., Efimova, E. V., Kaithamana, S., Martinez, O., El-Azami El-Idrissi, M., Dogan, R. E., Prabhakar, B. S. Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor-necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. J. Biol. Chem. 276: 47202-47211, 2001. 2. Anazi, S., Maddirevula, S., Salpietro, V., Asi, Y. T., Alsahli, S., Alhashem, A., Shamseldin, H. E., AlZahrani, F., Patel, N., Ibrahim, N., Abdulwahab, F. M., Hashem, M., and 31 others. Expanding the genetic heterogeneity of intellectual disability. Hum. Genet. 136: 1419-1429, 2017. Note: Erratum: Hum. Genet. 137: 105-109, 2018. 3. Chow, V. T. K., Lee, S. S. DENN, a novel human gene differentially expressed in normal and neoplastic cells. DNA Seq. 6: 263-273, 1996.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A02111-5

183 kDa

240 kDa

6

IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.