Anti-MAEL Antibody Picoband® 0,00647 Vervoeging

The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

FERM domain-containing protein 6; Willin; FRMD6; C14orf31

MAEL

84944

Q96JY0

Human

No cross-reactivity with other proteins.

E.coli-derived human MAEL recombinant protein (Position: E73-Q347) .

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Flow Cytometry

Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

1. Findley, S. D., Tamanaha, M., Clegg, N. J., Ruohola-Baker, H. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development 130: 859-871, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 7/29/2009. 3. Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., Bortvin, A. Mouse Maelstrom, a component of nuage, is essential for spermatogenesis and transposon regression in meiosis. Dev. Cell 15: 285-297, 2008. [PubMed: 18694567, images, related citations] [Full Text]

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

FERM domain containing 6

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.