Anti-MALT1 Antibody Picoband® 31.0550 Vervoeging

MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1), also called MLT or PARACASPASE, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al. (1999) and Akagi et al. (1999) mapped the MALT1 gene to chromosome 18q21. Using mouse models, Ruland et al. (2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B (NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.

Mucosa-associated lymphoid tissue lymphoma translocation protein 1;3.4.22.-; MALT lymphoma-associated translocation; Paracaspase; MALT1; MLT

MALT1

10892

Q9UDY8

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human MALT1.

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Flow Cytometry

Apoptosis, Caspases, Cell Biology, Intracellular, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. .

1. Akagi, T., Motegi, M., Tamura, A., Suzuki, R., Hosokawa, Y., Suzuki, H., Ota, H., Nakamura, S., Morishima, Y., Taniwaki, M., Seto, M. A novel gene, MALT1 at 18q21, is involved in t (11;18) (q21; q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene 18: 5785-5794, 1999. 2. Dierlamm, J., Baens, M., Wlodarska, I., Stefanova-Ouzounova, M., Hernandez, J. M., Hossfeld, D. K., De Wolf-Peeters, C., Hagemeijer, A., Van den Berghe, H., Marynen, P. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t (11;18) (q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 93: 3601-3609, 1999. 3. Ruland, J., Duncan, G. S., Wakeham, A., Mak, T. W. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19: 749-758, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

92 kDa

No cross reactivity with other proteins.

6

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Cytoplasm, perinuclear region . Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

Belongs to the peptidase C14B family.

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.