Anti-MAP1 MOAP1 Antilichaam

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Boster Bio Anti-MAP1 MOAP1 Antibody (Catalog # A08043) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

MAP-1, PNMA4, Modulator of apoptosis 1, Paraneoplastic antigen Ma4, MAP-1

MOAP1

Q96BY2

Human, Mouse

MAP-1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human MAP-1. The immunogen is located within the last 50 amino acids of MAP1.

Widely expressed, with high levels in heart and brain.

ELISA, WB

Apoptosis, Neuroscience, Signal Transduction

MAP1 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.

MAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08043

39513 MW

Modulator of apoptosis 1

Cytoplasm

Modulator of apoptosis 1

IgG

MAP1 Antibody is supplied in PBS containing 0.02% sodium azide.