Anti-MAP1LC3C Antilichaam

Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1) . MAP1LC3C belongs to the MAP1 LC3 family of proteins that form mature complexes with MAP1A and MAP1B which are thought to be important in the formation and development of axons and dendrites (2) . MAP1LC3C is one of three isoforms of MAP1LC3, the mammalian homolog of yeast ATG8, an essential autophagy protein. These isoforms exhibit distinct expression patterns and MAP1LC3C, like MAP1LC3A but not MAP1LC3B, is post-translationally modified, suggesting the three isoforms may have different physiological functions (3) .

Boster Bio Anti-MAP1LC3C Antibody (Catalog # A08533) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

LC3C, ATG8JAutophagy-related protein LC3 C

MAP1LC3C

Q9BXW4

Human

MAP1LC3C antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3C are known to exist. MAP1LC3C antibody is predicted to not cross-react with MAP1LC3A or MAP1LC3B.

MAP1LC3C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MAP1LC3C. The immunogen is located within the last 50 amino acids of MAP1LC3C.

Most abundant in placenta, lung and ovary.

ELISA, WB, IHC-P, IF

Autophagy

MAP1LC3C antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382) . May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643) .

MAP1LC3C antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

https://www.bosterbio.com/msds?sku=A08533

16852 MW

Microtubule-associated protein 1 light chain 3 gamma

Cytoplasm, cytoskeleton

Microtubule-associated protein 1 light chain 3 gamma

IgG

MAP1LC3C antibody is supplied in PBS containing 0.02% sodium azide.