Anti-MARVELD2 Antilichaam Picoband® fluoro550 Vervoeging

MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene. The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49) . Two transcript variants encoding different isoforms have been found for this gene.

MARVELD2

153562

Q8N4S9

Human, Rat

E.coli-derived human MARVELD2 recombinant protein (Position: R12-H496) . Human MARVELD2 shares 87% amino acid (aa) sequence identity with mouse MARVELD2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Chishti, M. S., Bhatti, A., Tamim, S., Lee, K., McDonald, M.-L., Leal, S. M., Ahmad, W. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. J. Hum. Genet. 53: 101-105, 2008. 2. Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., Tsukita, S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J. Cell Biol. 171: 939-945, 2005. 3. Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., Belyantseva, I. A., Forge, A., Riazuddin, S., Friedman, T. B. Tricellulin is a tight-junction protein necessary for hearing. Am. J. Hum. Genet. 79: 1040-1051, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.