Anti-MASPIN Antibody Picoband® (monoklonaal, 7G4E1) 310647 Vervoeging

SERPINB5 is also known as PI5 or maspin. Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. Maspin is expressed in the skin, prostate, testis, intestine, tongue, lung, and the thymus. Maspin is a member of the serpin superfamily of serine protease inhibitors.[1] The primary function of most members of this family is to regulate the breakdown of proteins by inhibiting the catalytic activity of proteinases. Through this mechanism of action, serpins regulate a number of cellular processes includingphagocytosis, coagulation, and fibrinolysis.

Cadherin-3; Placental cadherin; P-cadherin; CDH3; CDHP

SERPINB5

5268

P36952

Human

No cross-reactivity with other proteins.

E.coli-derived human MASPIN recombinant protein (Position: M1-A350) . Human MASPIN shares 88% and 89% amino acid (aa) sequence identity with mouse and rat MASPIN, respectively.

Clone: 7G4E1

Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Flow Cytometry

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

1. Blandamura S, et al. Maspin expression, subcellular localization and clinicopathological correlation in endometrial hyperplasia and endometrial adenocarcinoma. Histol Histopathol, 2014 Jun. 2. Taskiran C, et al. Maspin expression in endometrial hyperplasia and carcinoma, and its relation with angiogenesis. Eur J Gynaecol Oncol, 2014. 3. Triulzi T, et al. Maspin influences response to doxorubicin by changing the tumor microenvironment organization. Int J Cancer, 2014 Jun 15.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Cadherin 3, type 1, P-cadherin (placental)

Cell membrane. Single-pass type I membrane protein.

High mobility group protein B3

Mouse IgG2a

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.