Anti-Mast Cell Chymase/CMA1 Antibody Picoband® fluoro550 Vervoeging

Chymase is a major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. Chymase is mapped to 14q12. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.

Chymase;3.4.21.39; Alpha-chymase; Mast cell protease I; CMA1; CYH, CYM

CMA1

1215

P23946

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human CMA1 recombinant protein (Position: I22-N247) . Human CMA1 shares 75% and 74% amino acid (aa) sequences identity with mouse and rat CMA1, respectively.

Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. .

Flow Cytometry

Atherosclerosis, Cardiovascular, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Immunology, Innate Immunity, Macrophage/Inflammation, Signal Transduction, Vascular Inflammation

Immunogen affinity purified.

Liquid

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

1. Caughey, GH. Mast cell tryptases and chymases in inflammation and host defense. Immu Revs 2007 (217) : 141-154. 2. Chmelar, J., Oliveira, C. J., Rezacova, P., Francischetti, I. M. B., Kovarova, Z., Pejler, G., Kopacek, P., Ribeiro, J. M. C., Mares, M., Kopecky, J., Kotsyfakis, M. A tick salivary protein targets cathepsin G and Chymase and inhibits host inflammation and platelet aggregation. Blood 117: 736-744, 2011. 3. Urata, H., Boehm, K. D., Philip, A., Kinoshita, A., Gabrovsek, J., Bumpus, F. M., Husain, A.Cellular localization and regional distribution of an angiotensin II-forming Chymase in the heart. J. Clin. Invest. 91: 1269-1281, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

27325 MW

No cross reactivity with other proteins.

6

Chymase

Secreted. Cytoplasmic granule. Mast cell granules.

Belongs to the peptidase S1 family. Granzyme subfamily.

Chymase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.