Anti-MAT1A Antibody Picoband® 0,00647 Vervoeging

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

MAT1A

4143

Q00266

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the N-terminus of human MAT1A, identical to the related mouse and rat sequences.

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Flow Cytometry

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

1. Alvarez, L., Corrales, F., Martin-Duce, A., Mato, J. M. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem. J. 293: 481-486, 1993. 2. Blom, H. J., Davidson, A. J., Finkelstein, J. D., Luder, A. S., Bernardini, I., Martin, J. J., Tangerman, A., Trijbels, J. M. F., Mudd, S. H., Goodman, S. I., Gahl, W. A. Persistent hypermethioninaemia with dominant inheritance. J. Inherit. Metab. Dis. 15: 188-197, 1992. 3. Cabrero, C., Puerta, J., Alemany, S. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Europ. J. Biochem. 170: 299-304, 1987.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44 kDa

6

Transforming acidic coiled-coil-containing protein 1

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Transforming acidic coiled-coil-containing protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.