Anti-MAT2A Antibody Picoband® 0,00647 Vervoeging

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

MAT2A

4144

P31153

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MAT2A recombinant protein (Position: M1-A229) .

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

1. Chamberlin, M. E., Ubagai, T., Mudd, S. H., Wilson, W. G., Leonard, J. V., Chou, J. Y. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J. Clin. Invest. 98: 1021-1027, 1996. 2. De La Rosa, J., Ostrowski, J., Hryniewicz, M. M., Kredich, N. M., Kotb, M., LeGros, H. L., Jr., Valentine, M., Geller, A. M. Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. J. Biol. Chem. 270: 21860-21868, 1995. 3. Guo, D., Gong, L., Regalado, E. S., Santos-Cortez, R. L., Zhao, R., Cai, B., Veeraraghavan, S., Prakash, S. K., Johnson, R. J., Muilenburg, A., Willing, M., Jondeau, G., and 14 others. MAT2A mutations predispose individuals to thoracic aortic aneurysms. Am. J. Hum. Genet. 96: 170-177, 2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Chemokine (C motif) ligand 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.