Anti-MDH1 Antibody Picoband® fluoro488 Vervoeging

Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene. This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.

Calretinin; CR; 29 kDa calbindin; CALB2; CAB29

MDH1

4190

P40925

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MDH1 recombinant protein (Position: E56-A334) .

Brain.

Flow Cytometry

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Immunogen affinity purified.

Liquid

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

1. Ball, S. T., Moseley, H. J., Peters, J. Mor2, supernatant malate dehydrogenase, is linked to wa2 and Hba on mouse chromosome 11 in a region of homology with human chromosome 2p. Genomics 24: 399-400, 1994. 2. Birktoft, J. J., Fernley, R. T., Bradshaw, R. A., Banaszak, L. J. Amino acid sequence homology among the 2-hydroxy acid dehydrogenases: mitochondrial and cytoplasmic malate dehydrogenases form a homologous system with lactate dehydrogenase. Proc. Nat. Acad. Sci. 79: 6166-6170, 1982. 3. Blake, N. M., Kirk, R. L., Simons, M. J., Alpers, M. P. Genetic variants of soluble malate dehydrogenase in New Guinea populations. Humangenetik 11: 72-74, 1970.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Calbindin 2

Cuticular plate. Cytosol. Nucleus. Synaptic membrane. Dendrite. Gap junction. Neuron projection. Parallel fiber to Purkinje cell synapse. Presynapse. Stereocilium. Synapse.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.