Anti-MECR Antilichaam

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.

Boster Bio Anti-MECR Antibody (Catalog # A08189) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

NRBF1, CGI-63, FASN2B, NBRF1, Trans-2-enoyl-CoA reductase, mitochondrial, Nuclear receptor-binding factor 1, HsNrbf-1

MECR

Q9BV79

Human, Mouse, Rat

At least two isoforms of MECR are known to exist; this antibody will detect both isoforms.

Rabbit polyclonal MECR antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MECR. The immunogen is located within amino acids 300 - 350 of MECR.

Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.

ELISA, WB

Homeostasis

MECR Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II) . Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) .

MECR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

https://www.bosterbio.com/msds?sku=A08189

40462 MW

Mitochondrial trans-2-enoyl-CoA reductase

Isoform 1: Mitochondrion

Bovine

Mitochondrial trans-2-enoyl-CoA reductase

IgG

MECR Antibody is supplied in PBS containing 0.02% sodium azide.