Anti-MEK2/MAP2K2 Antibody Picoband® fluoro647 Vervoeging

Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2), also called PRKMK2 or MEK2, is an enzyme that in humans is encoded by the MAP2K2 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MAP2K2 is mapped to 19p13.3. This kinase is known to play a critical role in mitogen growth factor signal transduction, and the inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. Recombinant MEK2 and MEK1 both could activate human ERK1 in vitro, and they further characterized biochemically the 2 MAP2Ks. MAP2K2 has been shown to interact with MAPK3 and ARAF.

Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2;2.7.12.2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; MAP2K2; MEK2, MKK2, PRKMK2

MAP2K2

5605

P36507

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human MEK2, identical to the related mouse and rat sequences.

Flow Cytometry

Signaling Pathways, Stem Cells, Structures, Surface Molecules, Visual System

Immunogen affinity purified.

Liquid

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) . .

1.“Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2 2. Zheng, C. F., Guan, K. L. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268: 11435-11439, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44424 MW

No cross reactivity with other proteins.

6

Dual specificity mitogen-activated protein kinase kinase 2

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Dual specificity mitogen-activated protein kinase kinase 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.