Anti-MEK3/MAP2K3 Antibody Picoband® 310647 Vervoeging

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.

Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3;2.7.12.2; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2; MAP2K3; MEK3, MKK3, PRKMK3, SKK2

MAP2K3

5606

P46734

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human MEK3, identical to the related mouse and rat sequences.

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Flow Cytometry

Cancer, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, TLR Signaling, Transcription, Tyrosine Kinases

Immunogen affinity purified.

Liquid

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

1. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998) . Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. Cytogenet Cell Genet 78 (3-4) : 301–3.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39318 MW

No cross reactivity with other proteins.

6

Dual specificity mitogen-activated protein kinase kinase 3

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis.

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3/MAPKK 3)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.