Anti-MEKK2/MAP3K2 Antibody Picoband® fluoro647 Vervoeging

MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.

Mitogen-activated protein kinase kinase kinase 2;2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MAP3K2; MAPKKK2, MEKK2

MAP3K2

10746

Q9Y2U5

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK2, different from the related rat and mouse sequences by one amino acid.

Flow Cytometry

MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity) . Plays a role in caveolae kiss-and-run dynamics. .

1. Yao Z, et al. Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One, 2010 Sep 7. 2. Cazares LH, et al. Maging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin Cancer Res, 2009 Sep 1.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

69741 MW

No cross reactivity with other proteins.

6

Mitogen-activated protein kinase kinase kinase 2

Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Mitogen-activated protein kinase kinase kinase 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.