Anti-MERTK/Mer Konijn Monoklonale Antilichaam

Boster Bio Anti-MERTK/Mer Rabbit Monoclonal Antibody catalog # M00489. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Tyrosine-protein kinase Mer;2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER

MERTK

10461

Q12866

Human

A synthesized peptide derived from human MERTK

Clone: COI-13

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

WB, IHC, IP

Intracellular Signaling, Kinases, Neuroscience, Neurotransmission, Protein Phosphorylation, Receptor Tyrosine Kinases, Sensory System, Signal Transduction, Tyrosine Kinases, Visual System

Affinity-chromatography

0.5mg/ml

Liquid

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis) . Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00489

110249 MW

52 kDa

Tyrosine-protein kinase Mer

Membrane ; Single-pass type I membrane protein .

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.