Anti-MEST Antibody Picoband® 31.0550 Vervoeging

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene. This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.

MEST

4232

Q5EB52

Human, Mouse, Rat

E.coli-derived human MEST recombinant protein (Position: A21-D320) . Human MEST shares 97.7% and 98.3% amino acid (aa) sequence identity with mouse and rat MEST, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Decker, M., Adamska, M., Cronin, A., Di Giallonardo, F., Burgener, J., Marowsky, A., Falck, J. R., Morisseau, C., Hammock, B. D., Gruzdev, A., Zeldin, D. C., Arand, M. EH3 (ABHD9) : the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J. Lipid Res. 53: 2038-2045, 2012. 2. Ferguson-Smith, A. C., Cattanach, B. M., Barton, S. C., Beechey, C. V., Surani, M. A. Embryological and molecular investigations of parental imprinting on mouse chromosome 7. Nature 351: 667-670, 1991. 3. Kaneko-Ishino, T., Kuroiwa, Y., Miyoshi, N., Kohda, T., Suzuki, R., Yokoyama, M., Viville, S., Barton, S. C., Ishino, F., Surani, M. A. Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Nature Genet. 11: 52-59, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.