Anti-MFF Antibody Picoband® 31.0550 Vervoeging

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene. This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.

Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4; Ox40l; Txgp1l

MFF

56947

Q9GZY8

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MFF recombinant protein (Position: M1-R342) .

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Flow Cytometry

Adaptive Immunity, Autoimmune, B Cells, Cell Type Markers, Cytokines, Immune System Diseases, Immunology, Innate Immunity, T Cells, TNF Superfamily

Immunogen affinity purified.

Liquid

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

1. Gandre-Babbe, S., van der Bliek, A. M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Molec. Biol. Cell 19: 2402-2412, 2008. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 8/27/2012. 3. Koch, J., Feichtinger, R. G., Freisinger, P., Pies, M., Schrodl, F., Iuso, A., Sperl, W., Mayr, J. A., Prokisch, H., Haack, T. B. Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy. J. Med. Genet. 53: 270-278, 2016.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tumor necrosis factor (ligand) superfamily, member 4

Membrane; Single-pass type II membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.