Anti-MICALL2 Antibody Picoband® 31.0550 Vervoeging

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber.

Mediator of RNA polymerase II transcription subunit 9; Mediator complex subunit 9; MED9; MED25

MICALL2

79778

Q8IY33

Human

No cross-reactivity with other proteins.

E.coli-derived human MICALL2 recombinant protein (Position: K132-Q741) .

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

Flow Cytometry

Epigenetics and Nuclear Signaling, Mediator Complex, Pol II Transcription, Polymerase Associated Factors, RNA Polymerase, Transcription

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Sakane, A., Yano, T. A., Uchihashi, T., Horikawa, K., Hara, Y., Imoto, I., ... & Sasaki, T. (2021) . JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes. Communications biology, 4 (1), 551. 2. Zhu, L. Y., Zhang, W. M., Yang, X. M., Cui, L., Li, J., Zhang, Y. L., ... & Zhang, Z. G. (2015) . Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal–epithelial transition. Cancer letters, 363 (1), 71-82. 3. Min, P., Zhao, S., Liu, L., Zhang, Y., Ma, Y., Zhao, X., ... & Du, J. (2019) . MICAL‐L2 potentiates Cdc42‐dependent EGFR stability and promotes gastric cancer cell migration. Journal of cellular and molecular medicine, 23 (6), 4475-4488.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Mediator complex subunit 9

Nucleus .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.