Anti-MIG/CXCL9 Antibody Picoband® fluoro550 Vervoeging

MIG, also known as CXCL9, is a T-cell chemoattractant inducible by gamma interferon that is a member of the CXC chemokine family of cytokines. This gene is mapped to 4q21. It is noted that, although the best-described activities of the chemokines are as chemotactic factors, chemokines also have an effect on T-cell activation, angiogenesis, and HIV infection. While most CXC chemokines are chemotactic for neutrophils, MIG and INP10 are unusual and similar in being CXC chemokines that are chemotactic for lymphocytes and inactive in neutrophils.

C-X-C motif chemokine 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9; CXCL9; CMK, MIG, SCYB9

CXCL9

4283

Q07325

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCL9.

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. .

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

1. Lee HH, Farber JM (1996) . Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine mini-cluster. Cytogenet. Cell Genet. 74 (4) : 255–8. 2. O'Donovan N, Galvin M, Morgan JG (1999) . Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84 (1-2) : 39–42. 3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999) . Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) . J. Invest. Dermatol. 112 (5) : 716–22.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

14019 MW

No cross reactivity with other proteins.

6

C-X-C motif chemokine 9

Secreted.

Belongs to the intercrine alpha (chemokine CxC) family.

C-X-C motif chemokine 9

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.