Anti-Mimitin NDUFAF2 Antilichaam

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC) . Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-κB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

Boster Bio Anti-Mimitin NDUFAF2 Antibody (Catalog # A08718) . Tested in ELISA, WB, IF applications. This antibody reacts with Human.

MMTN, B17.2L, mimitin, NDUFA12L, Mimitin, mitochondrial, Myc-induced mitochondrial protein, MMTN

NDUFAF2

Q8N183

Human

Mimitin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Mimitin. The immunogen is located within the last 50 amino acids of Mimitin.

Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts.

ELISA, WB, IF

Cancer

Mimitin Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211) . Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371) .

Mimitin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08718

19856 MW

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2

Mitochondrion

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2

IgG

Mimitin Antibody is supplied in PBS containing 0.02% sodium azide.