Anti-MIOX Antibody Picoband® fluoro488 Vervoeging

Myo-inositol oxygenase (MIOX), also known as ALDRL6, is a renal-specific member of the Aldo-keto reductase family. It catalyzes the first committed step in the Myo-inositol metabolism pathway and is widely distributed in mammalian tissues. Human Myo-inositol oxygenase shares 91% and 96% sequence homology with mouse and pig Myo-inositol oxygenase homologs, respectively. Myo-inositol oxygenase is responsible for the oxidative cleavage of Myo-inositol (MI) and its epimer D-chiro inositol (DCI) to D-glucuronate. The dioxygen-dependent cleavage of the C1-C6 bond in Myo-inositol is accomplished through the utilization of the FeII/FeIII binuclear iron center of MIOX. Myo-inositol oxygenase has also been implicated in complications of diabetes, including diabetic nephropathy.

MIOX

55586

Q9UGB7

Human, Mouse, Rat

E.coli-derived human MIOX recombinant protein (Position: M1-K266) . Human MIOX shares 89.8% and 90.5% amino acid (aa) sequence identity with mouse and rat MIOX, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Arner, R. J., Prabhu, K. S., Thompson, J. T., Hildenbrandt, G. R., Liken, A. D., Reddy, C. C. Myo-inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. Biochem. J. 360: 313-320, 2001. 2. Gross, M. B. Personal Communication. Baltimore, Md. 3/31/2016. 3. Yang, Q., Dixit, J. B., Wada, J., Tian, Y., Wallner, E. I., Srivastva, S. K., Kanwar, Y. S. Identification of a renal specific oxido-reductase in newborn diabetic mice. Proc. Nat. Acad. Sci. 97: 9896-9901, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.