Anti-Mitofusin 2.2.2012 Konijn Monoklonale Antilichaam

Boster Bio Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody catalog # M00461. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Mitofusin-2;3.6.5.-; Transmembrane GTPase MFN2; MFN2; CPRP1, KIAA0214

MFN2

9927

O95140

Human, Mouse, Rat

A synthesized peptide derived from human Mitofusin 2

Clone: AOCA-13

Ubiquitous; expressed at low level. Highly expressed in heart and kidney. .

WB, IHC, ICC, IF

Mitochondrial Markers, Mitochondrial Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Affinity-chromatography

0.5mg/ml

Liquid

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) . Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00461

86402 MW

80 kDa

Mitofusin-2

Mitochondrion outer membrane ; Multi- pass membrane protein . Colocalizes with BAX during apoptosis.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.