Anti-Mkli1/MRTFA Antilichaam Picoband®

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.

Boster Bio Anti-Mkl1/MRTFA Antibody Picoband® catalog # A32468-2. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10; RTL10; BOP, C22orf29

MRTFA

57591

Q969V6

Human

No cross-reactivity with other proteins.

E.coli-derived human Mkl1/MRTFA recombinant protein (Position: L192-L931) .

Ubiquitously expressed.

ELISA, IF, ICC, WB

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.

1. Brandt, D. T., Baarlink, C., Kitzing, T. M., Kremmer, E., Ivaska, J., Nollau, P., Grosse, R. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta-1-integrin. Nature Cell Biol. 11: 557-567, 2009. 2. Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W., Prywes, R. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Molec. Cell. Biol. 23: 6597-6608, 2003. 3. Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K., Lammerding, J. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature 497: 507-511, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A32468-2

14377 MW

145 kDa

Retrotransposon Gag like 10

Cell membrane; Lipid-anchor, GPI-anchor.

Lymphocyte antigen 6A-2/6E-1

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.