Anti-MLKL Konijn Monoklonale Antilichaam

Boster Bio Anti-MLKL Rabbit Monoclonal Antibody catalog # M00535. Tested in WB, IHC applications. This antibody reacts with Human.

Mixed lineage kinase domain-like protein; hMLKL; MLKL

MLKL

197259

Q8NB16

Human

A synthesized peptide derived from human MLKL

Clone: DGB-13

Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level) . Isoform 3 is expressed in vascular smooth muscle cells (VSMC) . .

WB, IHC

Cancer, Cell Death, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Affinity-chromatography

0.5mg/ml

Liquid

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00535

54479 MW

40 kDa

Mixed lineage kinase domain-like protein

Cytoplasm . Cell membrane . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.