Anti-MLX Antibody Picoband® fluoro488 Vervoeging

Max-like protein X is a protein that in humans is encoded by the MLX gene. The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Aquaporin-5; AQP-5; AQP5

MLX

6945

Q9UH92

Human

No cross-reactivity with other proteins.

E.coli-derived human MLX recombinant protein (Position: R33-Y298) .

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Flow Cytometry

Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723) . Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723) .

1. Billin, A. N., Eilers, A. L., Coulter, K. L., Logan, J. S., Ayer, D. E. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a Max-like network. Molec. Cell. Biol. 20: 8845-8854, 2000. 2. Billin, A. N., Eilers, A. L., Queva, C., Ayer, D. E. Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. J. Biol. Chem. 274: 36344-36350, 1999. 3. Bjerknes, M., Cheng, H. TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. Gene 181: 7-11, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64406 MW

6

Aquaporin 5

Apical cell membrane.

Transcription factor E2F3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.