Anti-MLX-interactief eiwit MLXIP Antilichaam

MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1) . MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2) . MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3) .

Boster Bio Anti-MLX-interacting protein MLXIP Antibody (Catalog # A08709) . Tested in ELISA, WB applications. This antibody reacts with Human.

FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E

MLXIP

Q9HAP2

Human

MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.

Widely expressed in adult tissues. Most abundant in skeletal muscle.

ELISA, WB

Homeostasis

MLXIP Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

MLXIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08709

101185 MW

MLX interacting protein

Cytoplasm

Mouse

MLX interacting protein

IgG

MLXIP Antibody is supplied in PBS containing 0.02% sodium azide.