Anti-MOCS2 Antibody Picoband® 31.0550 Vervoeging

Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene. Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits.

Amyloid-beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3; APBA3; MINT3; X11L2

MOCS2

4338

O96007

Human

No cross-reactivity with other proteins.

E.coli-derived human MOCS2 recombinant protein (Position: M1-E168) .

Expressed in all tissues examined with lower levels in brain and testis.

Flow Cytometry

Interleukins

Immunogen affinity purified.

Liquid

May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.

1. Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., Adissu, H., Baker, C. N., Bower, L., and 73 others. High-throughput discovery of novel developmental phenotypes. Nature 537: 508-514, 2016. Note: Erratum: Nature 551: 398 only, 2017. 2. Hahnewald, R., Leimkuhler, S., Vilaseca, A., Acquaviva-Bourdain, C., Lenz, U., Reiss, J. A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase. Molec. Genet. Metab. 89: 210-213, 2006. 3. Johnson, J. L., Coyne, K. E., Rajagopalan, K. V., Van Hove, J. L. K., Mackay, M., Pitt, J., Boneh, A. Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency. Am. J. Med. Genet. 104: 169-173, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

108320 MW

6

Amyloid beta precursor protein binding family A member 3

Perinuclear region.

Gamma-aminobutyric acid type B receptor subunit 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.